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In general, the potency of a steroid is directly proportional to its side effects, though the dose used is a major determinant of steroid potency. The side effects of steroid therapy are discussed in the section: Side effects. Ingestion of steroids produces immediate adverse reactions that can be life threatening. In a healthy individual, these reactions usually do not lead to the severe physiological complications of steroid therapy. When steroid therapy is used for severe acute problems, the patient may need to discontinue the drugs for a short period of time. With prolonged therapy, the effect on the central nervous system may become permanent. The effectiveness of steroids as pain relief will vary with the duration of use. There are two key parameters which relate to the effect of steroids on pain: Dose-response ratio: The intensity of the steroid effect is determined by the number of injections required. The higher the dose used, the greater the effect, but the more the drug will be absorbed and the more time will be required for the patient to go through withdrawal symptoms. The intensity of the steroid effect is determined by the number of injections required. The higher the dose used, the greater the effect, but the more the drug will be absorbed and the more time will be required for the patient to go through withdrawal symptoms. Duration of action : A high dose of an anabolic steroid reduces the activity of the pain response. Anabolic steroids do not produce high levels of the peptide opioid receptor, but rather the drug induces a decrease in nociception. The drug-drug interaction matrix describes how these effects can occur. The interaction matrix includes a drug's half-life, the number of drugs in the drug system at any one time, and the potency of each drug. The interaction matrix is a summary of the available research that describes which of the many drugs on this list has which interaction and is therefore likely to trigger an adverse reaction. For example, if two steroids (Steroids A and B) have the same effect on pain, one of them may cause a temporary reduction in nociception, while the other may increase nociception. Another example is the combination of an anabolic steroid with a pain drug. Both drugs may cause an adverse response. In addition, side effects may occur that are not present in the treatment of severe pain. In such rare instances, the patient may be considered for surgery or other potentially life-threatening procedure after steroid therapy. Also, the side effects may persist up to up to several months after the last injection of the steroid, even after discontinuation Related Article: